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Trend in the Eradication Rates of Helicobacter pylori Infection in the Last 8 Years in Daegu: A Single Center Experience
The Korean Journal of Helicobacter and Upper Gastrointestinal Research ; : 236-242, 2015.
Article in Korean | WPRIM | ID: wpr-46974
ABSTRACT
BACKGROUND/

AIMS:

Helicobacter pylori eradication rates achieved by first-line triple treatment with proton pump inhibitor (PPI), clarithromycin, and amoxicillin have decreased to 70~85%, in part due to increasing antimicrobial resistance. This study evaluated the trend in H. pylori eradication rates during the most recent 8 years in Daegu, Korea and analyzed different clinical factors between success group and failure group of H. pylori eradication. MATERIALS AND

METHODS:

This was a retrospective study at a single institution. A total of 768 H. pylori-positive patients who received one or two weeks of first-line triple regimens were included between January 2007 and October 2014.

RESULTS:

The overall H. pylori eradication rate was 86%. The eradication rate from years 2007 to 2014 was 80.5%, 89.4%, 95.6%, 85.5%, 87.9%, 75.8%, 83.3%, and 85.8%, respectively (P=0.027). There was no significant difference in the eradication rate among various PPIs (P=0.358). In addition, there were no significant difference of clinical factors between success and failure group of H. pylori eradication.

CONCLUSIONS:

The eradication rates of first-line triple therapy for H. pylori over 8 years were 75.8~95.6%. No significant difference in clinical factors were noted between success and failure group of H. pylori eradication. Triple therapy may be a useful regimen for H. pylori eradication in Daegu.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Retrospective Studies / Helicobacter pylori / Helicobacter / Proton Pumps / Clarithromycin / Disease Eradication / Amoxicillin / Korea Type of study: Observational study Limits: Humans Country/Region as subject: Asia Language: Korean Journal: The Korean Journal of Helicobacter and Upper Gastrointestinal Research Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Retrospective Studies / Helicobacter pylori / Helicobacter / Proton Pumps / Clarithromycin / Disease Eradication / Amoxicillin / Korea Type of study: Observational study Limits: Humans Country/Region as subject: Asia Language: Korean Journal: The Korean Journal of Helicobacter and Upper Gastrointestinal Research Year: 2015 Type: Article