Non-motor symptoms in Parkinson's disease: a 2-years follow-up study on idiopathic / 中华老年医学杂志

ABSTRACT

Objective To study the prevalence and progression of non-motor symptoms (NMS) during 2 years follow-up in idiopathic PD patients,and to investigate the relationship of NMS with quality of life and motor symptoms.Methods A total of 82 idiopathic PD patients were involved in the survey.Unified Parkinson's Disease Rating Scale (UPDRS) and Non-Motor Symptoms Questionnaire for Parkinson's disease (NMSQuest) and Mini Mental State Examination (MMSE) were used to assess non-motor symptoms.Results The NMS total scores were higher at the end of follow-up than at baseline [(11.97±5.54) vs.(9.45±5.13),r=0.620,P=0.007].The scores of 6 symptoms including daytime salivation,constipation,photism or auditory hallucination,depression,sleep walking or somniloquy,diplopia,and 4 syndromes including digestive system,hallucination and delusion,cardiovascular system and other system were significantly increased.The symptoms of hallucination and delusion,and the decrease of recent memory at baseline had significant correlations with the decline of quality of life and the aggravation of motor symptoms (r=0.625,0.578,P=0.016,0.035).Conclusions NMS present in the whole course of PD and show rapid changes.NMS have correlations with the decline of quality of life and the aggravation of motor symptoms.