6-Thioguanine-Induced Hepatic Sinusoidal Obstruction Syndrome in a Leukemic Child with TPMT Heterozygote / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 109-113, 2012.
Article
in Korean
| WPRIM
| ID: wpr-47107
ABSTRACT
Hepatic sinusoidal obstruction syndrome (hSOS) can be developed as a common complication after hematopoietic stem cell transplantation (HSCT), and rarely after 6-thioguanine-based chemotherapy without HSCT. A four-year-old boy with heterozygotic polymorphism for thiopurine methyltransferase (TPMT) developed hSOS after he received chemotherapy with cytarabine, cyclophosphamide, intrathecal methotrexate and 6-thioguanine (6-TG) as reconsolidation chemotherapy of acute lymphoblastic leukemia (ALL). He was treated with defibrotide, N-acetylcysteine, urusodeoxycholic acid, glutathione, and supportive care. He recovered completely in nine days without long-term complication, and completed chemotherapy with 6-mercaptopurine without severe complication. We report a case of hSOS developed in an ALL patient with TPMT heterozygote after 6-TG based reconsolidation chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polydeoxyribonucleotides
/
Acetylcysteine
/
Thioguanine
/
Hepatic Veno-Occlusive Disease
/
Methotrexate
/
Hematopoietic Stem Cell Transplantation
/
Cyclophosphamide
/
Cytarabine
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Glutathione
Limits:
Child
/
Humans
Language:
Korean
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2012
Type:
Article
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