Effect of Formula Granule of Siwu Drugs on Sex Hormone and Its Receptor in Bone Marrow Depressed Mice / 天津医药
Tianjin Medical Journal
;
(12): 578-580, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-471253
ABSTRACT
Objective:
To investigate the effect of abstracted formula granule of Siwu drugs on the sex hormones and expressions of androgen receptor (AR)and estrogen receptor (ER) in bone marrow depressed mice.Methods:
One hundred and eighty mice (90 male and 90 female) were randomly divided into 6 groups. The effects of the formula granule of Siwu on sex hormones and expressions of AR and ER were explored by SABC method in bone marrow of depressed mice.Results:
For the male rats, the levels of androgen were increased in male of treatment groups compared with those of model groups (P<0.05), and the levels of estrogen were decreased in male of treatment groups compared with those of model groups (P<0.05).For the female rats, the levels of androgen were increased in female of treatment groups compared with those of model groups,but no significant differences (P>0.05), and the levels of estrogen were decreased in femal of treatment groups compared with those of model groups (P<0.05). There was a dose dependent manner between treatment groups.Conclusion:
The results suggested that formula granule of Siwu drugs may play a role in the hematopoietic function to repair bone marrow depression by improving AR and the balance of estrogen / androgen in mice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tianjin Medical Journal
Year:
2009
Type:
Article
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