Effect of Xylitol on the COX-2 Expression of Renal Tubule in Diabetic Rats / 天津医药
Tianjin Medical Journal
;
(12): 219-222, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-471739
ABSTRACT
Objective:
To observe the effect of xylitol on the cyclooxygenase(COX)-2 expression of renal tubule in diabetic rats.Methods:
The Wistar rats were randomly divided into normal control group(group NC),diabetes control group(group DC),5% xylitol-treated group(group 5%),10% xylitol-treated group(group 10%)and 20% xylitol-treated group(group 20%).At the end of 8 weeks,the expression of COX-2 in kidney tissue,the level of serum uric acid,allantoin and creatinine were tested in rat groups.Results:
The levels of serum uric acid and allantoin were higher in group 5% and group 10% compared with that of group DC.The differences in levels of serum uric acid and allantoin were statistical significance between group 10% and group DC(P < 0.05),whereas,the lower levels of serum uric acid and allantoin were found in group 20% compared with those of group DC(P > 0.05).The levels of urine uric acid and allantoin were lower in group 5% and group 10% than those of group DC(urine uric acid,P> 0.05 and allantoin,P< 0.05),whereas,group 20% had higher levels of urine uric acid and allantoin than those of group DC(P< 0.05).The fractional excretion of uric acid(FEUA)was lower in group 5% and group 10% compared with that of group DC(P < 0.05).The FEUA was higher in group 20% than that of group DC(P < 0.05).The expression of COX-2 was significantly increased in group 5% and group 10% compared with that of group DC(P < 0.05),but the expression of COX-2 decreased in group 20%(P < 0.05).Conclusion:
The lower and mediate doses of dietary xylitol could aggravate the tubular injury through increasing the level of serum uric acid and the expression of COX-2 in renal tubule.The higher doses of xylitol could increase the excretion of uric acid and down-regulate the expression of COX-2 in renal tubule.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tianjin Medical Journal
Year:
2010
Type:
Article
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