The Preemptive Analgesic Effect of Flurbiprofen on the Level of Cytokine in Patients Undergoing Neurosurgery / 天津医药
Tianjin Medical Journal
;
(12): 90-93, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-472355
ABSTRACT
Objective:
To investigate the preemptive analgesic effect of flurbiprofen on inflammatory cytokine in patients undergoing cerebral operation.Methods:
Forty ASA Ⅰ-Ⅱpatients undergoing cerebral surgery were randomly divided into control group(group C,n=20)and flurbiprofen group(group F,n=20).Flurbipmfen of 10 mL was given intravenously 15 min before skin incision.The values of VAS scores were recorded at 2 h,24 h and 48 h after operation.Blood samples were taken for determination of serum levels of TNF-α,IL-6 and IL-10 immediately before induction of anesthesia(T1,baseline),at 2 h of operation (T2),immediately after the end of operation (T3) and 24 h after operation (T4).The parameters of anaesthesia time,hemorrhage volume,urine volume,transfusion volume and the dosage of remifentanil and propofol were recorded during the period of anaesthesia.Results:
The VAS score was lower in group F than that in group C at 2 h and 24 h after operation (P<0.05),but there was no difference at 48 h after operation between the two groups(P>0.05).The dosages of remifentanil and propofol were lower during anaesthesia in group F than that in group C(P<0.05).Compared with T1,TNF-α was significantly increased at T2 and T3 in both groups,and the peak value at T2 (P<0.05).TNF-α was decreased at T2-T4 in group F than that in group C(P<0.05).Compared with T1,the levels of IL-6 and IL-10 were significantly increased at T2-T4 in both groups,and the peak value at T3(P<O.05).The value of IL-6 was decreased and the value of IL-10 was increased at T2-T4 in group F than those in group C (P<0.05).Conclusion:
Flurbiprofen was suitable as a preemptive analgesia and could suppress stress reaction of inflammatory in neurosurgery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tianjin Medical Journal
Year:
2010
Type:
Article
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