A new therapeutic strategy in myelodysplasia syndromes: modification of the epigenome / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 633-635, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-472390
ABSTRACT
The term epigenetics refers to a number of biochemical modifications of chromatin that, without altering the primary sequence of DNA, play a role in genomic regulation and in control of particular gene expression. These modifications involve several kinds, such as DNA methylation, histone code modifications and chromatin remodeling. It is accepted that these modifications is as common in solid tumors as it is in hematologic malignancies such as myelodysplastic syndromes(MDS). So many specialists suggest that the study of this area is very valuable. The current clinical information regarding different forms of epigenetic therapy in patients with MDS were focused in this review.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Leukemia & Lymphoma
Year:
2009
Type:
Article
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