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Magnetic resonance spectroscopy in observing thalamus metabolism of patients with multiple sclerosis or neuromyelitis optica / 中国介入影像与治疗学
Chinese Journal of Interventional Imaging and Therapy ; (12): 380-383, 2011.
Article in Chinese | WPRIM | ID: wpr-472583
ABSTRACT
ObjectiveTo investigate the variation of thalamus metabolism in patients with multiple sclerosis (MS) or neuronmyelitis optica (NMO) using 1H-MRS.Methods1H-MRS was performed to 32 MS patients (MS group),28 NMO patients (NMO group) and 35 healthy volunteers (normal control group).The ratios of metabolism in thalamus,including N-acetylaspartic acid/creatine (NAA/Cr),choline/creatine (Cho/Cr) and myo-inositol/creatine (mI/Cr) were calculated and compared.ResultsThere was statistical difference of NAA/Cr in thalamus among the three groups (P<0.05).NAA/Cr in thalamus of MS group was significantly lower than that of normal control group (t= -3.45,P<0.05),while no statistical difference of Cho/Cr and mI/Cr was found (t=0.086,0.661,all P>0.05).No statistical difference of NAA/Cr,Cho/Cr or ml/Cr was found between NMO group and normal control group (t=-0.792,1.408,1.735,all P>0.05).Conclusion1H-MRS shows the decrease of thalamus NAA/Cr that suggesting axon damage in MS patients,but in NMO patients no same result is found.1 H-MRS can reflect the pathological changes of MS and NMO,and improve the differential diagnosis of the two diseases.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Interventional Imaging and Therapy Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Interventional Imaging and Therapy Year: 2011 Type: Article