Effect of autologous bone marrow cells transplantation on myocardial function in patients with acute myocardial infarction:A Doppler echocardiographic observation / 中国医学影像技术

ABSTRACT

Objective To evaluate left ventricular function of acute myocardial infarction (AMI) patients who underwent autologous bone marrow mononuclear cells (BMMNC) after percutaneous coronary intervention (PCI) transplantation with tissue Doppler imaging (TDI). Methods Forty-eight male patients with AMI were divided into experimental group and control group (each n=24). PCI was performed within 24 hours after attach. Patients in experimental group received autologous BMMNC transplantation 7-14 days after PCI. Conventional echocardiography and TDI were performed before and 1, 3 and 6 months after treatment. Left ventricular ejection fraction (LVEF), peak systolic (S_a, S_m), early diastolic (E_a, E_m) and late diastolic (A_a, A_m) mitral velocities and regional myocardial velocities were obtained with conventional echocardiography or TDI, and compared between the two groups. Results There was no significant difference of each index between two groups before operation. Compared with the control group, S_a, S_m, E_m, E_a/A_a and Em/Am improved significantly in experimental group at each follow-up time point; LVEF and E_a were significantly higher than those of control group 3 and 6 months after treatment. Conclusion Combination of PCI and autologous BMMNC transplantation is more helpful to improve regional and global cardiac systolic and diastolic function after myocardial infarction, which can be quantitatively evaluated with TDI.