The development of novel tyrosine kinase inhibitors / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 316-318, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-472774
ABSTRACT
At the end of last century,the snlall-molecule selective kinase inhibitor,imatinib mesylate (IM),Was successfully exploited.This resulted in a revolutionary step in the treatment of chronic myeloid leukemia(CML).However,along with the expansion of its clinical application and the process,drug resistance Was commonly observed in patients, especially during accelerated or blast phases, and has become a significant therapeutic problem in clinical application.The problem has prompted the appearance of novel small molecule tyrosine kinase inhibitors,and its development is reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Leukemia & Lymphoma
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS