Research progress of relationship between tumor microenvironment and radioresistance / 肿瘤研究与临床

ABSTRACT

Tumor microenvironment is composed by tumor cells,stromal cells,immune-inflammatory cells,extracellular matrix,soluble cytokine and so on.Previous studies focused on the biological behavior,genetic changes and related phenotypic changes of tumor cells,but tumor microenvironment is closely related with the tumor development and treatment resistance.In recent years,new studies have confirmed that tumor microenvironment is an important member of tumor,which play an important role in proliferation,invasion and proliferation of tumor cells.This article mainly introduces the tumor microenvironment features,tumor-associated macrophage and tumor-associated fibroblasts,which led to the radioresistance of tumor.