Promising method for detection of tumor cell in vivo: photoacoustic flow cytometry / 肿瘤研究与临床

ABSTRACT

Photoacoustic flow cytometry (PAFC) is a novel flow cytometry which integrates high-pulse repetition-rate lasers,fast signal acquisition algorithms and focused ultrasound transducers to assess deep vessels.The technical principle is that the cells in blood or lymph flow are irradiated with several laser beams with different wavelengths,then laser-induced PT effects are detected by corresponding schematics.PAFC is characterized by its high efficiency,no invasion and real-time detection,which makes it possible to detect tumor cells in circulation or in lymphatic system dynamically and in real time.So for,it is considered as one of the most promising techniques in cancer research.This article will address the principle,application and several problems of PAFC.