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Effects of Moxibustion Pretreatment on GSH-Px,SOD and MDA in Gastric Mucosa of Rats with Stress Ulcer / 针灸推拿医学(英文版)
Journal of Acupuncture and Tuina Science ; (6): 17-20, 2011.
Article in Chinese | WPRIM | ID: wpr-473297
ABSTRACT

Objective:

To observe the effects of moxibustion pretreatment on Glutathione Peroxidase(GSH-Px),Superoxide Dismutase(SOD),and Malondialchehyche(MDA)in gastric mucosa of rats with stress ulcer,and to investigate the mechanism of moxibustion pretreatment preventing the oxidized injury of gastric mucosa.

Methods:

Forty-eight healthy SD rats were randomly allocated into 4 groups,namely control group,model group,acupoint moxibustion group,and non-acupoint moxibustion group.The ulcer model was developed by restraint and water immersion stress,Ulcer index(UI)was calculated with Guth method,and the contents of GSH-Px,and MDA and SOD activity in the gastric tissues were measured with chromatometry method.

Results:

Compared those in the model group and nonacupoint moxibustion group,moxibustion at Zusanli(ST 36)could decrease the UI(P<0.01)and MDA(P<0.05)contents,and increase the activity of GSH-Px(P<0.01)and SOD(P<0.05).

Conclusion:

Pretreatment of moxibustion at Zusanli(ST 36)could promote the recovery of gastric injury in rats induced by restraint and water immersion stress by enhancing the activity of GSH-Px and SOD,and lower MDA content.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Acupuncture and Tuina Science Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Acupuncture and Tuina Science Year: 2011 Type: Article