Advances on molecular mechanism of B cell development related with lymphomagenesis in human germinal centres / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 510-512, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-473421
ABSTRACT
Germinal center is a site of B cell maturation and development, in which B cell activation and differentiation was regulated by inherent complexity signal and transcription factors networks. Under the normal condition, the interaction between these transcription factors maintain dynamic stability of B cell in germinal center. When cytogenetic abnormalities or viral infection appear, a variety of.abnormal expression of transcription factors induced the imbalance of B cell signal networks regulation. manifested as abnormal B cell proliferation, apoptosis, and differentiation was blocked. B cell malignancies were often associated with genetic change of B cell and abnormal expression of transcription factors.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Leukemia & Lymphoma
Year:
2011
Type:
Article
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