CT perfusion imaging on hemodynamic analysis of non-stroke moyamoya disease / 实用放射学杂志

ABSTRACT

Objective To analyze characteristics of cerebral hemodynamic change of non-stroke patients with moyamoya disease. Methods Twelve cases of moyamoya disease,which were not detected in craniocerebral CT scans but confirmed by DSA (case group),and 10 cases of normal adults (control group)were recruited and performed perfusion imaging with multiple-row spiral CT,The hemodynamic parameters of specific brain structures were calculated in the two groups.Then,statistical analysis was conducted compa-ring the parameters of the two groups.Results The perfusion parameters were significantly different between regions in case group (P=0.000),while no significant difference was found in perfusion parameters among regions in control group(P >0.05).The cerebral blood volume in frontal lobe,temporal lobe,parietal lobe and basal ganglia were significantly higher in case group than the control group (P <0.01).The frontal cerebral blood flow (rCBF)in frontal lobe was lower in case group than the control group (P <0.05).The average through time (determined by MTT)in frontal lobe,temporal lobe and parietal lobe,as well as time to peak(TTP)of contrast agent in frontal lobe were longer in case group (P <0.05 ).Conclusion CT perfusion imaging can quantitatively reflect the hemodynamic changes of brain tissue and it is of great value in the evaluation of cerebral circulatory disturbance in patients with moyamoya disease whose brain morphological changes have not yet been presented.