Recent advances of ABCG1 in cholesterol transport / 医学研究生学报

ABSTRACT

Cholesterol is considered to play a critical role in cellular activities .However , high level of peripheral cholesterol is a risk factor for atherosclerosis .ABCG1 is a new member of ABCG1 transporter family, which is involved in cholesterol reverse transport . ABCG1 plays a crucial role in maintaining intracellular sterol homeostasis , but its exact function in atherosclerosis is still unclear .Eluci-dation of the mechanisms of ABCG 1 in intracellular sterol flux will provide important information that may link ABCG 1 to diseases of dys-regulated tissue lipid homeostasis .This review focuses on recent advances of ABCG 1 and its roles in cholesterol transport .