Correlation between Serum Level of Neuron Specific Enolase and Brain Damage in Patients with Ischemic Stroke / 天津医药

ABSTRACT

Objective To investigate the relationship between serum neuron-specific enolase (NSE) level and the severity of brain injury in patients with acute ischemic stroke. Methods A total of 100 patients with acute ischemic stroke, classified as total anterior circulation infarct (TACI), partial anterior circulation infarct (PACI), posterior circalation infarct (POCI) and lacunar infarct (LACI) were included in this study. The serum levels of NSE were detected and cerebral infarc-tion volumes were measured using 32-bit OsiriX imaging software. The correlation between serum level of NSE, cerebral in-farction volume and subtypes of ischemic stroke was analyzed. Results Patients were divided into NSE≤11.46μg/L group and NSE>11.46μg/L group. The scores of NIHSS[6.0(4.0, 10.0) vs 4.0(2.0, 6.0)]were higher, the infarction volumes[4.3 (1.3, 15.9) cm3 vs 0.8(0.4,4.3) cm3]were larger in NSE>11.46μg/L group (P<0.05). The serum NSE level showed statistical-ly significant difference between TACI and other groups (P<0.01). The increased serum NSE level was correlated with in-creased infarction volume (rs=0.417,P<0.01). There was a linear regression between serum NSE level and infarction vol-ume. Its linear regression equation was =2.438+0.100 X (Xinfarction volume;Yserum NSE level). Conclusion The se-rum NSE level may be helpful for the prediction of the severity of brain injured in patients with acute ischemic stroke.