Meaning of changes of interleukin-8 and C reactive protein levels after PCI in CHD patients / 心血管康复医学杂志

ABSTRACT

Objective:To explore interleukin (IL)-8 and C reactive protein (CRP) levels change after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD) .Methods:A total of 90 CHD patients , who hospitalized in our hospital from Mar 2010 to Dec 2012 ,were selected .According to their therapeutic methods , they were divided into PCI group (n=70) and conservative treatment group (n=20) .Another 20 healthy people were regarded as healthy control group .Changes of IL-8 and C reactive protein (CRP ) concentrations before and within 20d after treatment were compared among three groups .Results:Compared with before treatment ,on 1d af-ter treatment ,there were significant reductions in levels of IL-8 [ (63.22 ± 13.10) pg/ml vs .(31.58 ± 9.10) pg/ml] and CRP [ (14.59 ± 6.13) mg/L vs .(9.61 ± 2.35) mg/L] in PCI group ,IL-8 was significantly lower than that of conservative treatment group [(50.18 ± 19.31) pg/ml] ,P0.05. Conclusion:IL-8 and C reactive protein levels significantly reduce after PCI ,which can be treated as indexes evaluating PCI postoperative prognosis in CHD patients .