Progress in the study of clinical characteristics and pathogenesis of IDH1/2 gene mutations in acute myeloid leukemia patients / 白血病·淋巴瘤

ABSTRACT

Acute myeloid leukemia is a group of malignant tumor characterized by chromosome abnormality and/or gene mutations.Its pathogenesis is very complex.Gene mutations in IDH1/2 which encode metabolic enzyme were found by sequencing recently.This discovery aroused interest in the domestic and foreign research group.A series of clinical and basic research was also conducted.This review is based on these studies.