Research progress of PTEN pathway in anti-angiogenesis of tumors / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 634-636, 2013.
Article
in Zh
| WPRIM
| ID: wpr-473820
Responsible library:
WPRO
ABSTRACT
PTEN is a dual protein/lipid phosphatase.As a negative regulator of PI3K/Akt pathway,PTEN not only plays an important role in multiple cellular functions such as cell metabolism,proliferation,cell-cycle progression,but also modulates angiogenesis via down-regulating PI3K-Akt-VEGF-HIF pathway in many tumors.In this review,the recent studies on the roles and mechanisms of PTEN in regulating tumorigenesis and angiogenesis are discussed to explore PTEN as a favorable prospect target in the treatment of angiogenesis.
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Index:
WPRIM
Language:
Zh
Journal:
Journal of Leukemia & Lymphoma
Year:
2013
Type:
Article