The Relationship between Sclerostin and Bone Metabolism in Hyperthyroidism Patients / 天津医药

ABSTRACT

Objective To compare the differences of serum sclerostin (SOST) levels between hyperthyroidism pa-tients and euthyroidism healthy individuals, and the relationship between SOST levels and bone metabolism markers, bone mineral density (BMD) in hyperthyroidism patients. Methods Sixty hyperthyroidism patients were enrolled into the study, and 30 health individuals were allocated to control group. Sixty hyperthyroidism patients were sub-divided into normal BMD group and osteopenia/osteoporosis group according to the T-scores of BMD. The blood samples were collected for measuring thyroid function and serum SOST in all three groups. Values of thyroid autoimmune antibodies, parathyroid hormone (PTH), N-MID osteocalcin (N-MID), total of type 1 collagen amino terminal extension of the peptide (tP1NP) andβ-collagen spe-cial sequence (β-CTX) were also detected in 60 hyperthyroidism patients. Radius BMD, femoral neck BMD and lumber spine BMD were determined by dual-energy X-ray absorptiometry (DEXA) in hyperthyroidism patients. Results The lev-el of serum SOST was significantly higher in hyperthyroidism group than that in control group (P<0.01). The serum levels of SOST, N-MID, tP1NP,β-CTX and FT4 were significantly higher, and the value of PTH was significantly lower in osteopenia/osteoporosis group than those of normal BMD group (P<0.05). The serum level of SOST was positively correlated with free triiodothyronine (FT3) andβ-CTX (rs=0.380 and 0.296,P<0.01), and it was negatively correlated with PTH, total radius BMD, femoral neck BMD and lumber spine BMD in hyperthyroidism patients (rs=-0.485,-0.322,-0.266 and-0.455,P<0.05). Conclusion The higher serum SOST levels may be associated with the abnormalities of bone metabolism in hyperthy-roidism patients.