Expression of Ang-2 gene in acute lymphatic leukemia and its clinical significance / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 267-269, 2009.
Article
in Zh
| WPRIM
| ID: wpr-474231
Responsible library:
WPRO
ABSTRACT
Objective To study the expression levels and its clinical significance of angiopoietin 2 (Ang-2) gene in acute lymphatic leukemia(ALL). Methods The qualitative detection method was established with SYBR Green Ⅰ by real-time fluorescent quantitative PCR, and Ang-2 mRNA was measured in 51 cases of pre-therapeutic ALL. In addition, the expression of Ang-2 gene was also analyzed in 20 cases of non-malignant hematological diseases. Results The expression of Ang-2 gene was found in all the patients, and Ang-2 expression level in ALL patients was significantly higher than that of the controls (P<0.05). No significant relationship was found between Ang-2 expression level and clinical characteristics (age, haematogloblin, WBC count, platelet count, LDH, blast cells in peripheral blood, blast cells in bone marrow). The expression level of Ang-2 have no effect on one year replase rate and survival rate in ALL. Conclusion Ang-2 expression level in ALL patients was higher than that in non-malignant hematological diseases, and there may be no relationship with clinical manifestation, treatment and prognosis.
Full text:
1
Index:
WPRIM
Type of study:
Prognostic_studies
/
Qualitative_research
Language:
Zh
Journal:
Journal of Leukemia & Lymphoma
Year:
2009
Type:
Article