Correlation of the expression of interleukin-17 and interleukin-10 in psoriasis / 中国医师进修杂志

ABSTRACT

Objective To investigate the relationship between interleukin (IL)-17 and IL-10 in psoriasis.Methods The expression of IL-17 and IL-10 was measured by enzyme-linked immunosorbent assay in 32 patients with psoriasis (psoriasis group) and 30 normal controls (control group).The correlation of IL-17 and IL-10 was analyzed.Results The expression of IL-17 in psoriasis group was higher than that in control group[(57.59 ± 11.99) ng/L vs.(33.27 ± 6.49) ng/L] (t =9.84,P ＜ 0.01).The expression of IL-10 in psoriasis group was lower than that in control group [(25.38 ± 4.32) ng/L vs.(32.01 ± 5.54) ng/L] (t =5.27,P＜ 0.01).There was negative correlation between IL-17 and IL-10 in patients with psoriasis (r =-0.70,P ＜ 0.01).Conclusion The pathogenesis of psoriasis may be related to imbalance of IL-17 and IL-10.