Prevention of Allograft Rejection by Immune Tolerance / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 1-13, 2006.
Article
in Korean
| WPRIM
| ID: wpr-47498
ABSTRACT
The development of immunosuprressants has had a significant contribution to inhibition of acute allograft rejection. However, long-term graft survival has not been realized by immunosuppressants, probably because of their nonspecific suppression of T cell activity and nonimmune side effects. The ideal way to overcome the limitations of current immunosuppressants is to induce allograft-specific immune tolerance. Transplant immunologists are exerting their efforts in achieving transplantation tolerance using three different approaches; mixed hematopoietic chimerism, costimulatory blockade, and regulation by regulatory T cells. It is expected that transplantation tolerance will soon be established as a standard immunosuppressive regimen with little side effects in preventing and reversing allograft rejection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
T-Lymphocytes, Regulatory
/
Transplantation Tolerance
/
Chimerism
/
Allografts
/
Graft Survival
/
Immune Tolerance
/
Immunosuppressive Agents
Language:
Korean
Journal:
The Journal of the Korean Society for Transplantation
Year:
2006
Type:
Article
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