Dynamin-related protein 1-mediated mitochondrial fission and cerebral ischemia / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 306-310, 2015.
Article
in Zh
| WPRIM
| ID: wpr-475285
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WPRO
ABSTRACT
Dynamin-related protein 1 (Drpl) is a major protein for regulating mitochondrial fission.Its activity is associated with the post-translational modification,mainly including phosphorylation,ubiquitination,sumoylation,and S-nitrosylation.During the cerebral ischemia,Drpl is activated and translocates from the cytoplasm to the mitochondrial outer membrane,mediates mitochondrial fission and eliminates damaged mitochondria.Drpl plays the important roles in the pathological processes of ischemic neuronal apoptosis,necrotic apoptosis,and mitophagy.Excessive mitochondria fission or accumulation of damaged mitochondria will aggravate neuronal injury.
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Language:
Zh
Journal:
International Journal of Cerebrovascular Diseases
Year:
2015
Type:
Article