The influence of α-lipoic acid on nerve conduction velocity in the treatment of type 2 diabetes with peripheral neuropathy / 中国基层医药

ABSTRACT

Objective To observe the influence of α-lipoic acid on nerve conduction velocity in the treatment of type 2 diabetes with peripheral neuropathy,to provide a theoretical basis for clinical treatment.Methods 90 type 2 diabetes patients with peripheral neuropathy were included in this study.The patients were randomly divided into the observation group and the control group,45 cases in each group.The control group was given conventional therapy,containing hypoglycemic comprehensive intervention and neurotrophic treatment.The observation group was given αt-lipoic acid treatment,600mg/d,21d for a course of treatment.The motor and sensory nerve conduction velocity were measured by EMG after a course,and the peripheral neuropathy symptoms (limb pain,numbness,fever,cold,hypoesthesia) before and after treatment were observed,the clinical efficacy was evaluated.Results The motor nerve conduction velocity (median nerve,tibial nerve,peroneal nerve) and sensory nerve conduction velocity (median nerve,peroneal nerve) of the observation group after treatment were significantly higher than before treatment (t =3.946,4.175,3.887,3.915,4.034,all P ＜ 0.05),but the median nerve sensory conduction velocity of the control group had no significant difference before and after treatment(P ＞ 0.05).The motor nerve conduction velocity (median nerve,tibial nerve,peroneal nerve) and sensory nerve conduction velocity (median nerve,peroneal nerve) of the observation group after treatment were significantly higher than the control group (t =3.488,3.585,3.362,3.246,3.505,all P ＜ 0.05).The efficacy of limb pain,numbness,fever,cold,feeling diminished of the observation group were 71.43％,78.95％,62.5％,61.54％,59.26％,which were significantly higher than 36.36％,43.24％,21.4％,29.17％,28％ of the control group(all P ＜0.05).The total effective rate of the observation group was 84.44％,which was significantly higher than 64.44％ of the control group (x2 =6.925,P ＜ 0.05).Conclusion α-lipoic acid can improve the motor nerve conduction velocity and sensory nerve conduction velocity of type 2 diabetes patients with peripheral neuropathy,significantly relieve the positive symptoms of DPN and improve clinical efticacy,which is worthy of clinical use.