Research progress of hematopoietic stem cells location and its interaction with surrounding microenvironment / 白血病·淋巴瘤

ABSTRACT

Homing and engraftment of transplanted hematopoietic stem cells (HSCs) can directly influence the effect of the transplantation.Exploration on its spatial distribution,location and interaction with the bone marrow (BM) microenvironment is great significance.Since the BM cavity is closed and surrounded by thick compact bone,it makes a colossal challenge to track the transplanted HSCs in vivo directly.Recently,researchers used different innovative methods to observe the spatial distribution and interaction with the BM microenvironment of the transplanted HSCs.The present review summarized the progress in the HSCs transplantation.