Analysis of Human Papillomavirus Infection in Male Patients in Northeast of Sichuan / 现代检验医学杂志

ABSTRACT

Objective To investigate the distribution and the infection status of human papillomavirus (HPV)genotype in male outpatients with sexually transmitted diseases (STD)in Northeast of Sichuan.Methods Totally 259 male outpatients with STD were performed to examine for HPV-DNA genotype by using Polymerase chain reaction and gene chip technolo-gy.Results 202 samples had positive HPV among 259 samples,the positive rate was 77.99%.Among 202 samples of HPV infection,60.89% were infected by single HPV genetype,26.24% were infected by two HPV genetypes,12.87% were in-fected by multiple HPV genetypes;27.41% were infected by high risk HPV genotypes,74.13% were infected by low risk HPV genotypes.In the rate of HPV genetype infection,the percentages of HPV6,HPV11,HPV16,HPV43,HPV33 and HPV58 were 52.97%,48.51%,16.34%,6.93%,5.45% and 5.45% respectively,and the rates of other HPV genetype in-fection were less than 5.00%.Among different age groups of men,there were insignificant differences in the infection rates of HPV (χ2=2.31,P>0.05),but there were statistical significance in the infection rates of high risk HPV subtypes (χ2=9.79,P<0.05).Conclusion The situation of HPV infection was comparatively severe and the mainly HPV infection types were low risk HPV genotypes infection or single HPV genetype infection in Northeast of Sichuan male outpatients with STD.The most frequent infection of high risk HPV subtypes was HPV16,and the nexts were HPV33 and HPV58;HPV6 and 1 1 subtypes were the most HPV subtypes among the low risk HPV infections.