Clinical significance of cystatin C to early renal damage in puerperae / 国际检验医学杂志

ABSTRACT

Objective To investigate the serum concentration of cystatin C in puerperae and the relationship of cystatin C with e-rythrocyte count,leukocyte count,urine microalbumin and specific gravity.Methods The serum cystatin C,Cr,BUN and urine e-rythrocyte count,leukocyte count,urine microalbumin and specific gravity were detected in 232 puerperae and 200 healthy women. Multiple linear regression analysis was performed to analyze the relationship of cystatin C with urine erythrocyte count,leukocyte count,urine microalbumin and specific gravity.Results The concentration of cystatin C in the puerperal group was significantly higher than that in the normal control group(P <0.05).The concentrations of Cr,BUN in the puerperal group were significantly lower than that in the normal control group (P <0.05).The erythrocyte count and the leukocyte count,in the puerperal group were higher than those in the control group(P <0.05).The urine microalbumin was higher in the puerperal group than that in the con-trol group(P <0.05).There was no significant difference of specific gravity between them.In multiple linear regression analysis,a regression relationship was found between cystatin C(Y)and urine microalbumin(X1 )and specific gravity(X2 ).Regression relation-ship was not found between cystatin C and other indices.Conclusion Elevated serum cystatin C,together with urine microalbumin suggests early renal function change.They can be used to monitor renal function for the puerperae.