Role of inflammation in the mechanism of the commorbidity of depression and pain / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 893-896, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-476321
ABSTRACT
Comorbid depression and chronic pain are highly prevalent in individuals suffering from physical illness .Here, we critically examine that inflammation is the possible mechanism of comorbidity of pain and depression .These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein -coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates toxic kynurenine metabolites .We review the role of in-flammation in the mechanism of the commorbidity of depression and pain .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2015
Type:
Article
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