Protective effects of left-handed pantoprazole sodium on the rat model of gastric ulcer generated by pyloric ligation / 中国比较医学杂志
Chinese Journal of Comparative Medicine
; (6): 54-57, 2015.
Article
in Zh
| WPRIM
| ID: wpr-476333
Responsible library:
WPRO
ABSTRACT
Objective The aim of this study was to investigate the effect of left-handed pantoprazole sodium on rat models of gastric ulcer generated by pyloric ligation .Methods The rat models induced by pylorus ligation were treated with a single intravenous injection of left-handed pantoprazole sodium .The gastric ulcer inhibition rate , volume of gastric juice, activity of pepsin, and level of serum gastrin were determined and gastric mucosa tissue was examined by pathology . Results The gastric ulcer index , volume of gastric juice , activity of pepsin and level of serum gastrin in the rats pretreated with left-handed pantoprazole sodium (0.9, 1.8, 3.6 mg/kg, i.v.) were significantly lower than those in the model group .The lesions of gastric mucosa were also improved in the pantoprazole-treated groups .Conclusions Left-handed pantoprazole sodium has remarkable protective effects on the gastric mucosa in rat models of gastric ulcer induced by pyloric ligation.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Comparative Medicine
Year:
2015
Type:
Article