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Therapeutic effect and safety of warfarin on patients with atrial fibrillation / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine ; (6): 418-421, 2015.
Article in Chinese | WPRIM | ID: wpr-476351
ABSTRACT

Objective:

To observe the therapeutic effect and safety of warfarin on patients with atrial fibrillation.

Methods:

A total of 126 patients with atrial fibrillation from our hospital during Jun 2012-Jun 2013 were selected. According to hiding number random method,they were divided into aspirin group (n=63)and warfarin group (n=63).Coagulation function,blood lipid levels and end-point events were compared between two groups.

Results:

Compared with aspirin group,after treatment,there were significant reductions in levels of total cholesterol [(5.8 ±0.5)mmol/L vs.(5.2±0.7)mmol/L],triglyceride [(2.6±0.4)mmol/L vs.(2.4±0.3)mmol/L]and low density lipoprotein cholesterol [(2.7±0.5)mmol/L vs.(2.4±0.3)mmol/L],significant rise in level of high den-sity lipoprotein cholesterol [(1.1±0.2)mmol/L vs.(1.3±0.2)mmol/L],prothrombin time [(28.3±11.7)s vs. (36.9±10.4)s]and it′s international normalized ratio [(1.9±0.4)vs.(2.4±0.5)]in warfarin group,P 0.05.

Conclusion:

For atrial fibrillation,the therapeutic effect and safety of warfarin is better than that of aspirin,is worth extending.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2015 Type: Article