Effect of Flupentixol and Melitracen Combined with Proton Pump Inhibitor on Epigastric Pain Syndrome / 胃肠病学

ABSTRACT

Background:Epigastric pain syndrome( EPS),a subtype of functional dyspepsia,is commonly seen in clinical practice,and severely affects patients’quality of life. Aims:To observe the therapeutic efficacy of flupentixol and melitracen combined with proton pump inhibitor on EPS and its influence on psychological status and sleep quality. Methods:A total of 118 EPS patients from Jan. 2013 to June 2014 at Huangpi District People’s Hospital were enrolled, and were randomly divided into observation group and control group. Patients in control group were given esomeprazole 20 mg/ d,while patients in observation group were given flupentixol and melitracen 10. 5 mg bid in addition to esomeprazole,the treatment course were both for 8 weeks. Psychological status,quality of sleep and clinical therapeutic efficacy were compared between the two groups. Results:Four or 8 weeks after the treatment,anxiety,depression,sleep quality and clinical symptom were significantly ameliorated than before treatment in both two groups(P < 0. 05),while anxiety,depression and clinical symptom in observation group were significantly better than those in control group(P <0. 05). Therapeutic efficacy in observation group was significantly higher than that in control group(94. 9% vs. 79. 7% , P < 0. 05). No severe adverse reactions were found in both two groups. Conclusions:Flupentixol and melitracen combined with esomeprazole can effectively ameliorate anxiety and depression,and improve the therapeutic efficacy in EPS patients.