Expression and clinical significance of long non-coding RNA CRNDE in cervical cancer / 中国肿瘤临床

ABSTRACT

Objective:To investigate the expression and clinical significance of long non-coding RNA (LncRNA) CRNDE in cer-vical cancer. Methods:Specimens of cervical cancer tissues and matched non-tumor para-neoplastic tissues were collected from 87 pa-tients who underwent surgery in the Kaiping Central Hospital, China. Quantitative real-time PCR was used to examine the expression of LncRNA CRNDE, and its correlation with clinicopathological features was analyzed. Results:LncRNA CRNDE expression was sig-nificantly up-regulated in cervical cancer tissues than in adjacent non-tumor tissues (P<0.05). Increased LncRNA CRNDE expression was significantly correlated with FIGO stage, lymph node metastasis, and depth of cervical invasion (P<0.05). Moreover, a higher ex-pression of LncRNA CRNDE demonstrated significantly poorer overall survival in cervical cancer patients than in those with lower Ln-cRNA CRNDE expression (P<0.05). Multivariate analyses suggested that LncRNA CRNDE expression served as an independent pre-dictor for overall survival. Conclusion:Our findings posit that LncRNA CRNDE may be a potential prognostic marker and therapeutic target for cervical cancer.