Huangqi-Guizhi-Wuwudecoction for diabetic peripheral neuropathy / 国际中医中药杂志

ABSTRACT

ObjectiveTo evaluate the therapeutic effect ofHuangqi-Guizhi-Wuwu decoction in patients with diabetic peripheral neuropathy (DPN).MethodsA total of 78 patients with DNP were included and divided into a control group and a treatment group, with 39 in each group. The patients in the control group were administrated with appropriate exercise, control diet, hypoglycemics, mecobalamin and vitamin B1, those in the treatment group were receivedHuangqi-Guizhi-Wuwu decoction on the basis of the control group. The patients in both groups were treated for 8 weeks. The serum activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase were determined by enzymatic-colorimetric method, and the serum malondialdehyde level was measured using colorimetric method. Sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) were measured using an Electromyograph and Evoked Potential Equipment.ResultsAfter treatment, MCV (43.12 ± 4.1 m/svs. 40.27 ± 2.8 m/s;t=3.585,P<0.05)、SCV (41.51 ± 3.4 m/svs. 39.63 ± 3.5 m/s;t=2.406,P<0.05) in the treatment group were significantly increased than those in the control group. The serum activities of SOD (51.1 ± 6.6 U/mlvs. 47.6 ± 3.9 U/ml;t=2.851,P<0.01),GSH-Px (241.7 ± 36.1 U/mlvs. 213.9 ± 31.7 U/ml;t=3.614,P<0.01) in the treatment group were significantly increased than those in the control group. The total efficiency in the treatment group was significantly higher than that in the control group (87.2%vs. 69.2%;χ2=4.333,P=0.033).ConclusionsHuangqi-Guizhi-Wuwu decoction combined with conventional therapy could improve antioxidant capacity and control DPN progress in patients with DPN.