Experimental Penicillin-Induced Seizure
Journal of Korean Neurosurgical Society
;
: 427-434, 1981.
Article
in Korean
| WPRIM
| ID: wpr-47726
ABSTRACT
The penicillin produces seizures when applied directly to cerebral cortex and, in some instances, when given systemically in large amounts. Most studies with this agent have had as their goal the elucidation of neurophysiological mechanisms underlying seizure activity. The present study was undertaken to explore the biochemical events which take place in the presence of an epileptogenic agent and, in particular, to see whether this agent has a direct effect on passive or active cation transport or an effect on energy production within neural tissues. The penicillin-induced seizure activity has been produced by direct injection of an aqueous penicillin G sodium into the cerebral subarachnoid space in rat. It is assumed that penicillin-induced seizure results from the leakage of potassium ions from intracellular compartment and alteration of firing properties of neurons with prolonged depolarization, and disturbances in activities of enzyme involved in glutamine metabolism. Diphenylhydantoin may stimulate cation pumping with activation of (Na+-K+)-ATPase enzyme system and this action may be relevant to its anticonvulsant activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penicillin G
/
Penicillins
/
Phenytoin
/
Potassium
/
Seizures
/
Subarachnoid Space
/
Cerebral Cortex
/
Cation Transport Proteins
/
Fires
/
Glutamine
Limits:
Animals
Language:
Korean
Journal:
Journal of Korean Neurosurgical Society
Year:
1981
Type:
Article
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