Ring Chromosome 5 in Acute Myeloid Leukemia Defined by Whole-genome Single Nucleotide Polymorphism Array
Annals of Laboratory Medicine
;
: 307-311, 2012.
Article
in English
| WPRIM
| ID: wpr-47745
ABSTRACT
Chromosomes forming a corresponding ring cannot be clearly defined by conventional cytogenetics or FISH. Karyotypic analyses using whole-genome single nucleotide polymorphism arrays (SNP-A) may result in the identification of previously cryptic lesions and allow for more precise definition of breakpoints. We describe a case of AML with metaphase cells bearing -5, del(11)(q22), and +r. With SNP-A, a 5p-terminal deletion (11 megabases [Mb]), a 5q-terminal deletion (27 Mb), an 11q-interstitial deletion (29 Mb), and a 21q gain (3 Mb) were identified. Therefore, the G-banded karyotype was revised as 46, XY, r(5)(p15. 2q33.2), del(11)(q14.1q23.2), dup(21)(q22.13q22.2)[18]/46,XY[2]. SNP-A could be a powerful tool for characterizing ring chromosomes in which the involved chromosomes or bands cannot be precisely identified by conventional cytogenetics or FISH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ring Chromosomes
/
Chromosomes, Human, Pair 5
/
Leukemia, Myeloid, Acute
/
Chromosome Deletion
/
In Situ Hybridization, Fluorescence
/
Oligonucleotide Array Sequence Analysis
/
Polymorphism, Single Nucleotide
/
Karyotyping
/
Metaphase
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2012
Type:
Article
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