MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia
Annals of Laboratory Medicine
;
: 289-293, 2012.
Article
in English
| WPRIM
| ID: wpr-47749
ABSTRACT
MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel non-immunoglobulin partner locus. The patient was a 4-yr-old Korean boy with ALL of the precursor B-cell immunophenotype. At the time of the second relapse, cytogenetic analyses revealed t(4;8)(q31.1;q24.1) as a clonal evolution. The MYC rearrangement was confirmed by FISH analysis. He died 3 months after the second relapse without achieving complete remission. To our knowledge, this is the first report of a case of MYC rearrangement with a non-immunoglobulin partner in precursor B-cell lymphoblastic leukemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Translocation, Genetic
/
Chromosomes, Human, Pair 4
/
Chromosomes, Human, Pair 8
/
Immunoglobulins
/
Bone Marrow Cells
/
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/
Proto-Oncogene Proteins c-myc
/
Genetic Loci
/
Karyotyping
Limits:
Child, preschool
/
Humans
/
Male
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS