Temporal Reliability and Lateralization of Resting-state Language Functional Connectivity Network Analysis Based on Order Statistics Correlation Coefifcient / 中国医学影像学杂志

ABSTRACT

Purpose To investigate the activity of language network with brain function connection network analysis method using MRI order statistics correlation coefficient, and to explore the temporal reliability and functional asymmetry, and provide the theoretical foundation for clinical researches of resting-state language network.Materials and Methods Twenty-five healthy volunteers were scanned three times in resting state. All data were processed using 32 bit Matlab 7.11.0 and DPARSF. The two main language functional areas, Broca and Wernicke, were selected as the regions of interest. The functional connectivity of language network was analyzed with order statistics correlation coefficient.Results Based on the functional connectivity diagrams using seed analysis method, the asymmetry index and intra-class correlation were obtained. The functional connectivity of resting-state language network based on order statistics correlation coefficient was similar to that using the traditional correlation coefficient methods. Conclusion The temporal reliability of resting-state language network can provide a reference value for clinical research of language disorders, as well as the clinical diagnosis and treatment of the language disorders or mental diseases caused by abnormal functional asymmetry of language network.