Lipoprotein-associated phospholipase A2 and coronary heart disease / 中华检验医学杂志
Chinese Journal of Laboratory Medicine
;
(12): 493-497, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-477891
ABSTRACT
Lp-PLA2 is widely concerned in recent years as a vascular inflammation factor that plays an important role in the development of atherosclerosis .The level of plasma Lp-PLA2 is related to the stability of carotid artery atherosclerotic plaque .it is an independent predictor of coronary heart disease risk . Its specific inhibitor Darapladib also becomes a hotspot of clinical cardiovascular pharmaceutical research . However,two randomized, placebo-controlled, double-blind, international, multicenter, event-driven trials, STABILITY and SOLID-TIMI 52, have shown that Darapladib could not significantly reduce the risk of cardiovascular events.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Laboratory Medicine
Year:
2015
Type:
Article
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