Effect of Teprenone Combined with Rabeprazole on Prevention of Bleeding after Gastric ESD / 胃肠病学
Chinese Journal of Gastroenterology
;
(12): 546-549, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-478022
ABSTRACT
Background:
As a minimally invasive treatment of early gastric cancer,endoscopic submucosal dissection(ESD) proves it could reduce postoperative complications and improve the quality of patients’life. However,ESD-induced gastric ulcer remains a problem.Aims:
To evaluate the effect of teprenone combined with rabeprazole on post-ESD ulcer healing and prevention of bleeding after gastric ESD.Methods:
One hundred and twenty cases of early gastric cancer or precancerous lesion treated by gastric ESD were divided randomly into group A and group B. Patients in group A were given teprenone combined with rabeprazole,while patients in group B were given rabeprazole alone. The treatment course was 8 weeks. Delayed bleeding rate after ESD and ulcer healing in the two groups were compared.Results:
No significant difference was found in rate of delayed bleeding after ESD between the two groups(P = 0. 679). The stage of ulcer had no differences after 7 days of ESD(P > 0. 05),while showed a better healing stage in group A after 30 days and 60 days of ESD(P 0. 05).Conclusions:
Teprenone can effectively promote post ESD ulcer healing,especially in the early stage of healing,thus reducing the rate of bleeding after gastric ESD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Gastroenterology
Year:
2015
Type:
Article
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