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Effect of Teprenone Combined with Rabeprazole on Prevention of Bleeding after Gastric ESD / 胃肠病学
Chinese Journal of Gastroenterology ; (12): 546-549, 2015.
Article in Chinese | WPRIM | ID: wpr-478022
ABSTRACT

Background:

As a minimally invasive treatment of early gastric cancer,endoscopic submucosal dissection(ESD) proves it could reduce postoperative complications and improve the quality of patientslife. However,ESD-induced gastric ulcer remains a problem.

Aims:

To evaluate the effect of teprenone combined with rabeprazole on post-ESD ulcer healing and prevention of bleeding after gastric ESD.

Methods:

One hundred and twenty cases of early gastric cancer or precancerous lesion treated by gastric ESD were divided randomly into group A and group B. Patients in group A were given teprenone combined with rabeprazole,while patients in group B were given rabeprazole alone. The treatment course was 8 weeks. Delayed bleeding rate after ESD and ulcer healing in the two groups were compared.

Results:

No significant difference was found in rate of delayed bleeding after ESD between the two groups(P = 0. 679). The stage of ulcer had no differences after 7 days of ESD(P > 0. 05),while showed a better healing stage in group A after 30 days and 60 days of ESD(P 0. 05).

Conclusions:

Teprenone can effectively promote post ESD ulcer healing,especially in the early stage of healing,thus reducing the rate of bleeding after gastric ESD.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Gastroenterology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Gastroenterology Year: 2015 Type: Article