Intravenous injection of bleomycin induces pulmonary fibrosis in mice:a stability evaluation / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 6436-6443, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-478165
ABSTRACT
BACKGROUND:
It is particularly important to establish an ideal animal model of pulmonary fibrosis to investigate the underlying pathogenesis and screen effective drugs to prevent and control pulmonary fibrosis.OBJECTIVE:
To establish a modified scheme of establishing mouse models that can reflect pulmonary fibrosis formation in humans.METHODS:
Fifty-six male C57BL/6 mice were randomly divided into two groups A (a single large-dose injection) and B (multiple smal-dose injections). Mice in group A were subjected to a single intravenous injection of bleomycin 200 mg/kgviathe tail vein; and mice in group B received intravenous injections of bleomycin 50 mg/kg via the tail vein per week, totaly for 6 weeks. 
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2015
Type:
Article
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