Correlation among serum BNP,testosterone, FT3 levels and heart function in male patients with chro-nic heart failure / 心血管康复医学杂志

ABSTRACT

Objective:To explore the correlation among serum levels of brain natriuretic peptide (BNP) ,testosterone (T) , free three triiodothyronine (FT3) and heart function ,prognosis in male patients with chronic heart failure (CHF) .Meth‐odsA total of 116 male CHF patients (CHF group) and 40 male patients with cardiovascular diseases and normal cardiac function (normal cardiac function group ) were enrolled .According to NYHA cardiac function class ,CHF group was divid‐ed into classⅡ group (n=41) ,class Ⅲ group (n=37) and class Ⅳ group (n=38);according to presence of cardiovascular events or not ,CHF group was divided into cardiovascular event group (n=36 ,event group) and non- cardiovascular event group (n=80 ,non- event group) .Serum levels of BNP ,T and FT3 were compared among above groups ,and the correla‐tions among those indexes and cardiac function were analyzed .Results:Compared with normal cardiac function group ,ser‐um BNP level significantly rose ,serum levels of T and FT significantly reduced in CHF group ( P<0.01 all) .Compared with classⅡ group ,serum BNP level significantly rose [(262.13 ± 125.08) ng/L vs .(674.65 ± 189.29) ng/L vs .(1072.91 ± 362.74) ng/L] in class Ⅲ group and class Ⅳ group ,and that of class Ⅳ group was significantly higher than that of classⅢ group;there were significant reductions in serum levels of T [(5.87 ± 1.12)μg/L vs .(4.56 ± 0.98)μg/L vs .(3.52 ± 0.74)μg/L] and FT3 [(4.70 ± 0.64) pmol/L vs .(3.68 ± 0.59) pmol/L vs .(2.18 ± 0.61) pmol/L] in class Ⅲ group and class Ⅳ group ,and those of class Ⅳ group were significantly lower than those of class Ⅲ group , P<0.05 or <0.01. Com‐pared with non - event group , there was significant rise in serum BNP level [(684.28 ± 192.76 ) ng/L vs . (992.63 ± 327.58) ng/L] ,and significant reductions in serum levels of T [(5.68 ± 1.04)μg/L vs .(3.35 ± 0.97)μg/L] and FT3 [(4.41 ± 0.78) pmol/L vs .(2.31 ± 0.62) pmol/L] in event group ,P<0.01 all .Linear correlation analysis indicated that cardiac function class was positively correlated with serum BNP level (r=0.314 ,P=0.023) ,and inversely correlated with serum T and FT3 levels(r= -0.272 ,-0.167 ,P=0.028 ,0.034) .Conclusion:Serum BNP ,T and FT3 levels are closely related with heart function in male CHF patients ,may provide important reference bases for diagnosis and evaluating prognosis .