Icariin inhibits TNF-αexpression in periodental tissue during root resorption induced by rapid palatal expansion / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6): 776-779, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-478347
ABSTRACT
Objective:
To evaluate the effect of icariin on TNF-αexpression in periodental tissue during root resorption induced by ropid palatal expansion in rats.Methods:
24 male Wistar rats were divided randomly into 3 groups(n =8)as group A(none-expansion control group),B(expansion group)and C(icariin and expansion group).In group B and C,an initial force of 50 g was applied to the area between the right and left upper first molars of the rats for 2 weeks for palatal expansion.The rats of group C were given intragastric administration of icariin at 2.5 mg/(kg·d)while the rats of group A and B were given the same dose place-bo.The centered buccal-lingual root and peridentium tissue slices were generated from the upper first molars of the rats.HE stai-ning of the slices was performed.The expression of TNF-αprotein at the compression sites was detected by irnmunohistochemistry.Results:
The A values of TNF-αof group A,B and C were 0.030 2 ±0.001 7,0.241 0 ±0.002 4 and 0.088 6 ±0.002 8 respec-tively(B vs A or C,P <0.05).Conclusion:
Icariin may inhibit TNF-αexpression in periodental tissue during root resorption in-duced by rapid palatal expansion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Journal of Practical Stomatology
Year:
2015
Type:
Article
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