Analysis of genetic polymorphism of cytochrome CYP2C19 in Chinese Uighur,Kazak and Han populations / 重庆医学

ABSTRACT

Objective To identify the genotype and allele distribution feature of cytochrome CYP2C19 in Chinese Uighur , Kazak and Han populations ,and by detecting the CYP2C19 genotype .Methods Finding out the differences of genotype distribution among the three Chinese nationalities .The 750 inpatients were selected from Second Department of Internal Medicine ,Cadres Ward of First Affiliated Hospital of Xinjiang Medical University .The CYP2C19 genotypes of the unrelated patients were assessed by pol‐ymerase chain reaction and restriction fragment length polymorphism .Results Six different CYP2C19 genotypes were determined in this study .There was a significant difference among the three Chinese nationalities (P< 0 .05) .The rate of fast metabolism type in Kazak is 93 .8% more than the rate of Han populations .The rate of slow metabolism type in Kazak is 6 .2% less than the rate of Han populations .The difference was statistically significant (P= 0 .006) .Conclusion Nationality has significant effect on genetic polymorphism of CYP2C19 in Chinese Uighur ,Kazakand and Han populations .