Anti-inflammatory effects of 4,4'-diaminodiphenyl sulfone (dapsone) in lipopolysaccharide-treated spleen cells: selective inhibition of inflammation-related cytokines / 대한수의학회지
Korean Journal of Veterinary Research
;
: 199-204, 2015.
Article
in Korean
| WPRIM
| ID: wpr-47858
ABSTRACT
4,4'-diaminodiphenyl sulfone (dapsone) is a sulfone drug that has antibacterial effects on a variety of bacteria, especially Mycobacterium leprae; thus, it has been used to treat leprosy. Previous studies demonstrated that dapsone inhibits integrin-mediated adherence of neutrophils and production of prostaglandin E2 by polymorphonuclear leukocytes. Hence, dapsone may act in immune cells and regulate cell-mediated inflammation processes. However, its anti-inflammatory effects remain unclear. The present study demonstrated that dapsone modulates the production of inflammation-related cytokines in immune cells. We employed the spleen cells of mice, which are major immune cells, and lipopolysaccharide (LPS) as a causative agent of inflammation for experiments. Dapsone induced a proportional change in splenocyte subsets and the apoptosis of spleen cells. Interestingly, dapsone decreased the production of tumor necrosis factor-alpha and interleukin (IL)-10, but not IL-6, in LPS-treated spleen cells. In other assays, we measured the dapsone-induced production of nitric oxide (NO) and the expression of activation markers of spleen cells. Dapsone decreased NO production in LPS-treated spleen cells. Taken together, our results demonstrate that dapsone has anti-inflammatory effects in immune cells and provide new insight into the potential uses of this agent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spleen
/
Bacteria
/
Dinoprostone
/
Cytokines
/
Interleukins
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Apoptosis
/
Dapsone
/
Inflammation
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Veterinary Research
Year:
2015
Type:
Article
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