Correlation Study Between Serum Growth Differentiation Factor-15 and Acute Ischemic Stroke / 中国循环杂志

ABSTRACT

Objective: To investigate the effect of serum growth differentiation factor-15 (GDF-15) in patients with acute ischemic stroke (AIS). Methods: Our research included 2 groups AIS group,n=120 patients and Control group,n=60 normal subjects from regular physical examination. The serum levels of GDF-15 were examined within 24 hours of AIS attack by ELISA in both groups, the relationship between GDF-15 and the neurologic impairment was assessed. According to modiifed ranking scale score after 3 months follow-up study, the AIS patients were further divided into 2 sub-groups Disabled group, the patients with MRS ≥ 2, n=65 and Non-disabled group, the patients with MRS < 2,n=55. The GDF-15 levels were compared between 2 sub-groups. Results: GDF-15 level in AIS group was 1594.00 (1128.00-2411.00) ng/L which was signiifcantly higher than that in Control group 656.00 (507.00-764.00) ng/L,P<0.05. GDF-15 level was positively related to neurologic impairment in AIS patients (r=0.390, P<0.001). Modiifed ranking scale score indicated that after 3 months of follow-up study, GDF-15 level in Disabled group was 2411 (2188-2569) ng/L which was much higher than that in Non-disabled group 1128 (980-1597) ng/L, (Z=-5.684,P<0.001). Conclusion: The serum level of GDF-15 was higher in AIS patients than normal subjects, it was positively related to neurologic impairment, AIS patients with higher GDF-15 would have poor prognosis.