Relationship Between Prolactin Cleavage and the Occurrence of Hypertension, Heart Failure in Post-menopausal Female Patients / 中国循环杂志
Chinese Circulation Journal
;
(12): 1058-1062, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-479460
ABSTRACT
Objective:
To investigate the relationship between prolactin (PRL) cleavage and the occurrence of hypertension, heart failure (HF) in post-menopausal female patients.Methods:
A total of 216 post-menopausal female subjects were enrolled in our study and they were divided into 3 groups Hypertension group,n=80 patients with essential hypertension, Hypertension + HF group,n=76 and Control group,n=60 post-menopausal women form regular physical examination. The full length (23 kD PRL), 16 kD PRL fragment, lipid peroxide (LPO), total antioxidant status (TAS), left ventricular ejection fraction (LVEF), NT-proBNP, creatinine, uric acid, fasting blood glucose (FBG) and BMI were examined and compared among different groups.Results:
①There were no real differences in age, creatinine, uric acid, FBG and BMI among groups,P>0.05.②Compared with Control group, Hypertension group had increased LPO and decreased TAS; compared with Control group and Hypertension group, Hypertension + HF group had increased LPO and decreased TAS.③Compared with Control group, Hypertension + HF group showed lower level of 23KD PRL, higher level of 16KD PRL and the higher ratio of 16KD PRL/23KD PRL,PConclusion:
PRL cleavage was highly related to the occurrence of hypertension and HF in post-menopausal female patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Circulation Journal
Year:
2015
Type:
Article
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