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Preparation of a deactivation vaccine against Aeromonas hydrophila and research about its immue effect in the north of Henan / 中国免疫学杂志
Chinese Journal of Immunology ; (12): 1501-1504, 2015.
Article in Zh | WPRIM | ID: wpr-479480
Responsible library: WPRO
ABSTRACT
Objective:Selected virulence factors more than and high virulent Aeromonas hydrophia strain made into inactivated vaccine,to study the immunization effect of inactivated vaccine.Methods:Crucian were vaccinated with formalin-killed vaccine via in-traperitoneal injection.Controls were injected with the same volumes of saline.Then the antibody titres, histopathology and relative percent survival were analyzed from samples of both groups.Results: The antibody in the indirect agglutination reaction could be detected in vaccinated fish once a weeks after immunization and reached highest level 6 weeks after immunization.The histopathology analysis indicated that the vaccine had a good protective effect on crucian target organs.Vaccinated fish showed 100%relative percent survival and the immune period would be 6 month.Conclusion:The vaccine in this study has a significant protective effect on crucian and may be used as effective fish vaccines against bacterial septicemia.
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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Immunology Year: 2015 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Immunology Year: 2015 Type: Article