Pro-inflammatory Cytokine Expression of Spleen Dendritic Cells in Mouse Toxoplasmosis
The Korean Journal of Parasitology
;
: 109-114, 2011.
Article
in English
| WPRIM
| ID: wpr-47952
ABSTRACT
Dendritic cells have been known as a member of strong innate immune cells against infectious organelles. In this study, we evaluated the cytokine expression of splenic dendritic cells in chronic mouse toxoplasmosis by tissue cyst-forming Me49 strain and demonstrated the distribution of lymphoid dendritic cells by fluorescence-activated cell sorter (FACS). Pro-inflammatory cytokines, such as IL-1alpha, IL-1beta, IL-6, and IL-10 increased rapidly at week 1 post-infection (PI) and peaked at week 3 PI. Serum IL-10 level followed the similar patterns. FACS analysis showed that the number of CD8alpha+/CD11c+ splenic dendritic cells increased at week 1 and peaked at week 3 PI. In conclusion, mouse splenic dendritic cells showed early and rapid cytokine changes and may have important protective roles in early phases of murine toxoplasmosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rodent Diseases
/
Spleen
/
Time Factors
/
Dendritic Cells
/
Toxoplasmosis, Animal
/
Cytokines
/
CD8 Antigens
/
CD11c Antigen
/
Disease Models, Animal
/
Flow Cytometry
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2011
Type:
Article
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